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Z-BRAIN: A Zebrafish Drug Screening Platform Targeting Brain Disorders

Project Overview

The traditional target-based drug development strategy (in vitro screening) has had poor success in developing new drugs. The vast majority of Investigational New Drugs (INDs) fail in clinical trials due to toxicity or lack of efficacy. On the other hand, mammalian models are excellent tools to stud…

See researchers on this project
Principal Investigator:
  • Xiao-Yan Wen, St. Michael's Hospital
Team Members:
  • Pierre Drapeau, CHUM Research Centre, University of Montréal
  • Raymond Andersen, University of British Columbia
  • Robert Gerlai, University of Toronto
  • Georg Zoidl, York University
  • Loch Macdonald, St. Michael's Hospital
  • Andrew Baker, St. Michael's Hospital
  • Albert Wong, Centre for Addiction and Mental Health
  • Marc Ekker, University of Ottawa
  • Sidney H. Kennedy, University Health Network
  • Alan Fine, Dalhousie University
  • Janice Robertson, University of Toronto
  • Vince Tropepe, University of Toronto
  • Henry Krause, University of Toronto
  • Terry Van Raay, University of Guelph
  • Tom Schweizer, St. Michael's Hospital
  • David Munoz, St. Michael's Hospital
  • Corinne Fischer, St. Michael's Hospital
  • Thomas Steeve, St. Michael's Hospital
  • Ted Allison, University of Alberta
  • Cheryl Gregory-Evans, University of British Columbia
  • Claudia dos Santos, St. Michael's Hospital