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6 result(s) found

Novel Cellular and Molecular Mechanisms Regulating Synapse Dysfunction in Alzheimer’s Disease

Project Overview

In Alzheimer s disease (AD), critical synaptic connections between neurons disintegrate and cells die. The brains of individuals with AD accumulate plaques of a protein fragment called AΠ that disrupt synapse function and cause neuronal death. Dr. Kennedy and his team will study a protein called …

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Principal Investigator:
  • Timothy Kennedy, McGill University

Novel mechanisms regulating intraneuronal Tau clearance as potential targets for Alzheimer’s disease

Project Overview

In Alzheimer’s disease (AD), the accumulation of toxic Tau protein in neurons leads to the formation of neurofbillary tangles, cell death, and cognitive impairments. The precise regulation of Tau levels in neurons is therefore essential to the survival of neurons, and defects in these mechanisms l…

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Principal Investigator:
  • Michel Cayouette, Institut de Recherches Cliniques de Montréal, Université de Montréal

Role of mitochondrial c-Src kinase in Alzheimer’s disease

Project Overview

Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). It is important to understand how the regulation of mitochondria is impaired in AD. The c-Src kinase has appeared as an important regulator of mitochondria. The aim of this research program is to…

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Principal Investigator:
  • Etienne Hebert-Chatelain, Université de Moncton

Strains of A-beta aggregates in Alzheimer’s disease

Project Overview

The existence of different strains of misshapen proteins in the brains of Alzheimer’s disease (AD) patients is emerging as an obstacle to the development of effective treatments. Recent research has revealed that the proteins that accumulate in the brain during AD are reminiscent of prions, which …

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Principal Investigator:
  • Joel Watts, Krembil Research Institute

The interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease

Project Overview

Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD. Enhancers are elements in the DNA code that enable the complex expression of genes. Epigenetic marks control enh…

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Principal Investigator:
  • Viviane Labrie, Centre for Addiction and Mental Health